中文名：乳酸

国际站：Lactate | 乳酸

AS：50-21-5

品牌：MedChemExpress (MCE)

存储条件：Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：乳酸（Lactate acid）是糖酵解的产物。乳酸是由于体内收缩骨骼肌缺氧而产生的，可以在完全有氧条件下去除。乳酸可以作为危重患者的血流动力学指标^[1][2]。

体外：Lactate (Lactic acid；20 mM；24、48 小时) 导致细胞增殖和迁移显着减少，作用并将细胞代谢转变为氧化磷酸化[1]。 Lactate (20 mM；24 小时) 显示 MCT1 和 HCAR1 的蛋白质和 mRNA 表达水平增加[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Lactate (Lactic acid；1.6 g/kg；皮下注射；每天一次；第 8 天至 30 天) 在 MC38 结肠癌模型中显示出 CD8+ T 细胞依赖性肿瘤生长抑制作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C57BL/6 mice with MC38 colon cancer cells[2] Dosage: 1.6 g/kg Administration: Subcutaneous; daily from Day 8 to 30 days Result: Significantly suppressed tumor growth. Clinical Trial

参考文献：

[1]. Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24(1):24.

[2]. Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13(1):4981.