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[News commentary] 人类灵魂的生物基础是什么?

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发表于 2017-8-11 01:51:41 | 显示全部楼层 |阅读模式
生死定时的生物基础是什么?

Thought about this, but didn't know how to approach, I admitted this's a brilliant angle to approach this question:

"how aging affects the biological clock’s control of metabolism have discovered that a low-calorie diet helps keep these energy-regulating processes humming and the body younger."

“The low-calorie diet greatly contributes to preventing the effects of physiological aging,” said Salvador Aznar Benitah, who co-led the Spanish study. “Keeping the rhythm of stem cells ‘young’ is important because in the end these cells serve to renew and preserve very pronounced day-night cycles in tissue. Eating less appears to prevent tissue aging and, therefore, prevent stem cells from reprogramming their circadian activities.”

My mentor used to say, don't do exercise as you waste the energy of heart beats - your heart is designed to beating so many times in life. I didn't know if any science research behind that number of heart beating.

Another topic excites me: What's the biological basis of human soul?

~~
Google translation of above:

想到这一点,但不知道怎么去,我承认这是一个辉煌的角度来解决这个问题:

“老化如何影响生物钟对新陈代谢的控制已经发现,低热量饮食有助于保持这些能量调节过程的嗡嗡声和身体更年轻。​

西班牙研究组织的萨尔瓦多·阿斯纳尔·贝尼塔(Salvador Aznar Benitah)说:“低热量饮食大大有助于预防生理衰老的影响。 “保持干细胞的节奏”年轻“是重要的,因为这些细胞最终可以更新和保存组织中非常明显的昼夜循环。 减少饮食似乎预防组织老化,因此防止干细胞重新编程其昼夜节律活动。“

我的导师曾经说过,不要做运动,因为你浪费了心跳的能量 - 你的心被设计为在生命中跳动了很多次。 我不知道是否有任何科学研究背后的这个数量的心跳。

另一个话题激发了我:人类灵魂的生物基础是什么?

**

https://www.newswise.com/articles/link-between-biological-clock-and-aging-revealed  

Link Between Biological Clock and Aging Revealed

UCI-led study shows low-calorie diet may help keep body young




Article ID: 679232

Released: 8-Aug-2017 1:30 PM EDT

Source Newsroom: University of California, Irvine

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MEDIA CONTACT

Available for logged-in reporters only


CITATIONS

Cell Aug. 10


CHANNELS

Aging, Cell Biology, Cell (journal), Local - California, All Journal News


KEYWORDS

•Metabolism, Aging, Caloric Restriction, Circadian Rhythm




Newswise — Irvine, Calif. — Scientists studying how aging affects the biological clock’s control of metabolism have discovered that a low-calorie diet helps keep these energy-regulating processes humming and the body younger.

In a study appearing Aug. 10 in the journal Cell, Paolo Sassone-Corsi, director of the Center for Epigenetics & Metabolism at the University of California, Irvine, and colleagues reveal how circadian rhythms – or the body’s biological clock – change as a result of physiological aging. The clock-controlled circuit that directly connects to the process of aging is based on efficient metabolism of energy within cells.

The Sassone-Corsi team tested the same group of mice at 6 months and 18 months, drawing tissue samples from the liver, the organ which operates as the interface between nutrition and energy distribution in the body. Energy is metabolized within cells under precise circadian controls.

The researchers found that the 24-hour cycle in the circadian-controlled metabolic system of older mice remained the same, but there were notable changes in the circadian mechanism that turns genes on and off based upon the cells’ energy usage. Simply put, the older cells processed energy inefficiently.

“This mechanism works great in a young animal, but it basically shuts off in an old mouse,” Sassone-Corsi said.

However, in a second group of aged mice that were fed a diet with 30 percent fewer calories for six months, energy processing within cells was more than unchanged.

“In fact, caloric restriction works by rejuvenating the biological clock in a most powerful way,” Sassone-Corsi said. “In this context, a good clock meant good aging.”

Collaborative confirmation

For a companion study detailed in Cell’s current issue, a research team from the Barcelona Institute for Research in Biomedicine collaborated with the Sassone-Corsi team to test body clock functioning in stem cells from the skin of young and older mice. They too found that a low-calorie diet conserved most of the rhythmic functions of youth.

“The low-calorie diet greatly contributes to preventing the effects of physiological aging,” said Salvador Aznar Benitah, who co-led the Spanish study. “Keeping the rhythm of stem cells ‘young’ is important because in the end these cells serve to renew and preserve very pronounced day-night cycles in tissue. Eating less appears to prevent tissue aging and, therefore, prevent stem cells from reprogramming their circadian activities.”

According to the UCI and Barcelona researchers, these studies can help explain why a calorie-restricted diet slows down aging in mice. The implications for human aging could be far-reaching.

The scientists said that it’s important to further examine why metabolism has such a dominant effect on the stem cell aging process and, once the link that promotes or delays aging has been identified, to develop treatments that can regulate this link.

It’s been shown in previous fruit fly studies that low-calorie diets can extend longevity, but the UCI and Barcelona research is the first to show that calorie restriction influences the body’s circadian rhythms’ involvement with the aging process in cells.

“These studies also present something like a molecular holy grail, revealing the cellular pathway through which aging is controlled,” Sassone-Corsi said. “The findings provide a clear introduction on how to go about controlling these elements of aging in a pharmacological perspective.”

The circadian connection

Sassone-Corsi and his colleagues first showed the circadian rhythm-metabolism link some 10 years ago, identifying the metabolic pathways through which a circadian enzyme protein called SIRT1 works. SIRT1 senses energy levels in cells; its activity is modulated by

how many nutrients a cell is consuming. In addition, it helps cells resist oxidative and radiation-induced stress. SIRT1 has also been tied to the inflammatory response, diabetes and aging.

Sassone-Corsi, the Donald Bren Professor of Biological Chemistry at UCI, is one of the world’s leading researchers on circadian rhythms, epigenetics and metabolism. Shogo Sato, Leonardo Bee and Selma Masri of UCI; Guiomar Solanas, Francisca Oliveira Peixoto and Aikaterini Symeonidi with the Barcelona Institute for Research in Biomedicine; and Mark Schmidt and Charles Brenner of the University of Iowa also contributed to the study, which received support from the National Institutes of Health and the French National Institute of Health & Medical Research, or INSERM.

About the University of California, Irvine: Founded in 1965, UCI is the youngest member of the prestigious Association of American Universities. The campus has produced three Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UCI has more than 30,000 students and offers 192 degree programs. It’s located in one of the world’s safest and most economically vibrant communities and is Orange County’s second-largest employer, contributing $5 billion annually to the local economy. For more on UCI, visit www.uci.edu.

Media access: Radio programs/stations may, for a fee, use an on-campus ISDN line to interview UCI faculty and experts, subject to availability and university approval. For more UCI news, visit news.uci.edu. Additional resources for journalists may be found at communications.uci.edu/for-journalists.


https://www.newswise.com/articles/link-between-biological-clock-and-aging-revealed  
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