http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=78695  Abstract

Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease. The etiology of RA is complex, then it is impossibleto cure completely today and it should be individualized treatment. Immunesystem is complex. Existing statistical techniques based on reductionism cannotdiscovermanyrelevant disease risk factors andcomplexinteraction relationship. The disease network model based on complex network is importantfor the analysis and treatment of RAdisease. In this Review, we have found five important layers of RA complex network and presented five balances regulatingstrategy in the management of RA. Wehave followed up one RA patient (wife of the author) for one year using thisstrategy, and the management effect is good. This Review argues RA is self-limiting to some extent, good management with fivebalances regulating strategy would have positive significance, among which thebalancebetween neuroendocrine system and immune system is themost important. During the day,glucocorticoid plays an important role in controlling inflammation, and humangrowth hormone plays an important role in eliminating inflammation during theslow-wave sleep at night.Five balances coreconcepts can shed light on the management of other causes of arthritis.

Keywords

Rheumatoid arthritis, Autoimmune diseases, Complex network, Balance, Network medicine

Zou, S. (2017) Five Balances in the Management of Rheumatoid Arthritis. Journal of Biosciences and Medicines, 5, 10-21. doi: 10.4236/jbm.2017.59002.