CRISPR/Cas9沉默高胆固醇相关基因

生物医学工程师使用CRISPR/CAS9基因工程技术来关闭一种调节成年小鼠胆固醇水平的基因，单次治疗后导致持续六个月的血液胆固醇水平降低和基因阻遏。

CRISPR/Cas9 silences gene associated with high cholesterol

https://www.sciencedaily.com/releases/2018/04/180426125937.htm

1. Pratiksha I. Thakore, Jennifer B. Kwon, Christopher E. Nelson, Douglas C. Rouse, Matthew P. Gemberling, Matthew L. Oliver, Charles A. Gersbach. RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-04048-4