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系统神经科学新进展:抑制性神经元

已有 3992 次阅读 2013-11-4 13:31 |个人分类:系统神经科学|系统分类:论文交流| 神经元

最近《自然》和《自然•神经科学》同时发表了两篇关于VIP+抑制性神经元在神经回路中的作用。借此机会,回顾总结了一下近年来对三种主要的抑制性神经元的研究(如下)。总的来说,系统神经科学在研究重点从兴奋性神经元转向抑制性神经元、麻醉动物转向清醒动物、从in vitro转向in vivo.


Electrophysiology properties of PV+ and SOM+ inhibitory neurons in primary visual cortex in anesthetized mice (Liu et al., 2009; Kerlin et al., 2010; Ma et al., 2010; Runyan et al., 2010)

Effect of PV+, SOM+ inhibitory neurons on excitatory neurons in primary visual cortex in anesthetized or awake mice (Atallah et al., 2012; Lee et al., 2012; Wilson et al., 2012)

Electrophysiology properties of SOM+ inhibitory neuron and its effect on excitatory neuron in primary somatosensory cortex in awake behaving mice (Gentet et al., 2012)

Local circuits SOM+ inhibitory neuron and excitatory neuron in primary visual cortex in anesthetized and awake mice (Adesnik et al., 2012)

Effect of PV+, SOM+ inhibitory neurons on excitatory neurons in CA1 in behaving mice (Royer et al., 2012)

Local circuits among inhibitory neuron in layer 1 in acute rat sensorimotor cortex slice (Jiang et al., 2013)

SOM+ inhibitory neuron in primary somatosensory cortex in acute mouse slice (Xu et al., 2013)

Local circuits among PV+, SOM+ and VIP+ in acute mouse slice (Pfeffer et al., 2013)

Circuitry function of VIP+ inhibitory neuron in behaving mice (Lee et al., 2013; Pi et al., 2013)


Reference

Adesnik H, Bruns W, Taniguchi H, Huang ZJ, Scanziani M (2012) A neural circuit for spatial summation in visual cortex. Nature 490:226-231.

Atallah BV, Bruns W, Carandini M, Scanziani M (2012) Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli. Neuron 73:159-170.

Gentet LJ, Kremer Y, Taniguchi H, Huang ZJ, Staiger JF, Petersen CC (2012) Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex. Nat Neurosci 15:607-612.

Jiang X, Wang G, Lee AJ, Stornetta RL, Zhu JJ (2013) The organization of two new cortical interneuronal circuits. Nat Neurosci.

Kerlin AM, Andermann ML, Berezovskii VK, Reid RC (2010) Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex. Neuron 67:858-871.

Lee S, Kruglikov I, Huang ZJ, Fishell G, Rudy B (2013) A disinhibitory circuit mediates motor integration in the somatosensory cortex. Nat Neurosci.

Lee SH, Kwan AC, Zhang S, Phoumthipphavong V, Flannery JG, Masmanidis SC, Taniguchi H, Huang ZJ, Zhang F, Boyden ES, Deisseroth K, Dan Y (2012) Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature 488:379-383.

Liu BH, Li P, Li YT, Sun YJ, Yanagawa Y, Obata K, Zhang LI, Tao HW (2009) Visual receptive field structure of cortical inhibitory neurons revealed by two-photon imaging guided recording. J Neurosci 29:10520-10532.

Ma WP, Liu BH, Li YT, Huang ZJ, Zhang LI, Tao HW (2010) Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses. J Neurosci 30:14371-14379.

Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M (2013) Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nature neuroscience.

Pi H-J, Hangya B, Kvitsiani D, Sanders JI, Huang ZJ, Kepecs A (2013) Cortical interneurons that specialize in disinhibitory control. Nature.

Royer S, Zemelman BV, Losonczy A, Kim J, Chance F, Magee JC, Buzsaki G (2012) Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition. Nat Neurosci.

Runyan CA, Schummers J, Van Wart A, Kuhlman SJ, Wilson NR, Huang ZJ, Sur M (2010) Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex. Neuron 67:847-857.

Wilson NR, Runyan CA, Wang FL, Sur M (2012) Division and subtraction by distinct cortical inhibitory networks in vivo. Nature 488:343-348.

Xu H, Jeong HY, Tremblay R, Rudy B (2013) Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4. Neuron 77:155-167.





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