Scientific social network
个人简介 (CV)
先后毕业于武汉大学，意大利国际高等研究院（SISSA），获学士和博士学位。2005-08年在慕尼黑大学基因中心（Gene Center Munich）进行博士后研究，获Dr. Klaus Römer奖金。现任中国医学科学院病原生物学研究所结构生物学课题长；“协和学者特聘教授”；获人社部高层次回国留学人才资助，教育部“新世纪优秀人才支持计划”。从事冠状病毒、肠道病毒等重要RNA病毒入侵和复制机制研究。主持了 “国家自然科学基金”等多项国家级项目和“ICGEB CRP”等国际项目。以通讯作者及第一作者在《Science》，《Sci Adv.》,《Mol Cell》，《Nat Commun.》，《Nucleic Acid Res.》，《PNAS》，《IUCrJ》，《PLOS Pathog》，《FASEB J.》,《J Biol Chem.》和《J Virol.》等期刊上发表研究论文。
Since 2009: Principal Investigator, Institute of Pathogen Biology at Chinese Academy of Medical Science.
2005-08: Postdoc, Hopfner's group, Gene Center, University of Munich.
2000-04: Ph.D., ICGEB & SISSA, Trieste Italy;
1993-97: B.S., Wuhan University.
Since 2009: Principal Investigator, Institute of Pathogen Biology at Chinese Academy of Medical Science.
2005-08: Postdoc, Hopfner's group, Gene Center, University of Munich.
2000-04: Ph.D., ICGEB & SISSA, Trieste Italy;
1993-97: B.S., Wuhan University.
Research interests
We are interested in understanding the structural basis and molecular mechanism underlying virus entry and replication. These processes are important for identifying antiviral targets and drug design, therefore, structure determination of proteins involving in entry or replication will provide invaluable information for drug development. Particularly, we have two focuses: employing hybrid and integrated methods in structural biology to study 1) the interplay between virus glycoprotein (HIV Env, CoV spike, etc.) and their cellular receptors. 2) the structure and function of virus replicases (helicase, proteinase, etc.) and the assembly of virus replication-transcription complex.
Recent publications
Crystal structure of the NS3-like helicase from Alongshan virus. Gao XP, Zhu KX, Justyna AW, Chen P [...] Cui S*. IUCrJ. 2020 May
Crystal Structure of Middle East Respiratory Syndrome Coronavirus Helicase. Wei Hao [...] Sheng Cui*. PLOS Pathogens. 2017 Jun 26;13(6):e1006474.
Crystal Structure of 2C ATPase from Enterovirus 71. Hongxin Guan [...] Sheng Cui*. Science Advances, 28 Apr 2017: Vol. 3, no. 4, e1602573
Crystal Structure of the Receptor Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1. Xiuyuan Ou#, Hongxin Guan# [...] Zhaohui Qian* Sheng Cui*. Nat Commun. 2017 May 23;8:15216.
Crystal Structure of Middle East Respiratory Syndrome Coronavirus Helicase. Wei Hao [...] Sheng Cui*. PLOS Pathogens. 2017 Jun 26;13(6):e1006474.
Crystal Structure of 2C ATPase from Enterovirus 71. Hongxin Guan [...] Sheng Cui*. Science Advances, 28 Apr 2017: Vol. 3, no. 4, e1602573
Crystal Structure of the Receptor Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1. Xiuyuan Ou#, Hongxin Guan# [...] Zhaohui Qian* Sheng Cui*. Nat Commun. 2017 May 23;8:15216.
- Sirt5是SARS-Cov-2的前病毒因子，可以与Nsp14相互作用 2022-03-31
- SARS-CoV-2 ORF10通过线粒体自噬降解MAVS抑制抗病毒天然反应 2022-01-11
- 抗病毒新药莫努匹拉韦的具体作用机制 2021-12-27
- KREMEN1和ASGR1被鉴定为SARS-CoV-2的替代功能性受体 2021-12-15
- TRIM7蛋白能够抑制肠道病毒的复制，促进毒性增强型的病毒突变体的产生 2021-11-02
人才招聘(Job opportunity)
2020年项目聘用人员职位1-2名
欢迎对病毒入侵、复制机制和基于结构的抗病毒药物设计感兴趣的同学加入；专业要求：生物化学，病毒学，免疫学，生物物理或计算机等专业均可。
有意愿在北京协和医学院就读研究生的申请者优先。
待遇和优势
1、岗位由医学与健康科技创新工程长期稳定支持；
2、具有硕士生学位的同学可择优推荐报考博士。
（有意者直接Email联系）。 联系方式：崔胜：cui.sheng@ipbcams.ac.cn；或 秦博： qbone@163.com
欢迎对病毒入侵、复制机制和基于结构的抗病毒药物设计感兴趣的同学加入；专业要求：生物化学，病毒学，免疫学，生物物理或计算机等专业均可。
有意愿在北京协和医学院就读研究生的申请者优先。
待遇和优势
1、岗位由医学与健康科技创新工程长期稳定支持；
2、具有硕士生学位的同学可择优推荐报考博士。
（有意者直接Email联系）。 联系方式：崔胜：cui.sheng@ipbcams.ac.cn；或 秦博： qbone@163.com
