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2019生理学或医学引文桂冠奖获得者
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2019生理学或医学引文桂冠奖获得者
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根据科睿唯安（Clarivate Analytics）2019年9月24日公布的2019年引文桂冠奖获奖者名单，来自7个国家的19位科学家荣获“引文桂冠奖”，生理学或医学领域的“引文桂冠奖”获奖科学家共6人，其获奖者截图如下，仅供参考。
Hans Clevers，荷兰乌得勒支大学分子遗传学教授，胡布雷克特研究所(KNAW)和普林斯马克西玛儿科肿瘤中心首席研究员。
获奖原因：针对Wnt信号通路及其在干细胞和癌症中的作用研究，提供了一个新药物测试的环境，可以在不使用细胞系或实验动物的情况下进行药物试验。
高引论文（被引频次>1200次）
| 标题 | 引用次数 | 年份 |
|---|---|---|
| Wnt/β-catenin signaling in development and disease H Clevers Cell 127 (3), 469-480 | 5066 | 2006 |
| Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC PJ Morin, AB Sparks, V Korinek, N Barker, H Clevers, B Vogelstein, ... Science 275 (5307), 1787-1790 | 4309 | 1997 |
| Identification of stem cells in small intestine and colon by marker gene Lgr5 N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ... Nature 449 (7165), 1003 | 3872 | 2007 |
| Wnt signalling in stem cells and cancer T Reya, H Clevers Nature 434 (7035), 843 | 3821 | 2005 |
| Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma V Korinek, N Barker, PJ Morin, D Van Wichen, R De Weger, KW Kinzler, ... Science 275 (5307), 1784-1787 | 3547 | 1997 |
| Wnt/β-catenin signaling and disease H Clevers, R Nusse Cell 149 (6), 1192-1205 | 3490 | 2012 |
| Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ... Nature 459 (7244), 262 | 2899 | 2009 |
| The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells M Van De Wetering, E Sancho, C Verweij, W De Lau, I Oving, A Hurlstone, ... Cell 111 (2), 241-250 | 2122 | 2002 |
| XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos M Molenaar, M van de Wetering, M Oosterwegel, J Peterson-Maduro, ... Cell 86 (3), 391-399 | 1930 | 1996 |
| Caught up in a Wnt storm: Wnt signaling in cancer RH Giles, JH Van Es, H Clevers Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1653 (1), 1-24 | 1757 | 2003 |
| Crypt stem cells as the cells-of-origin of intestinal cancer N Barker, RA Ridgway, JH van Es, M van de Wetering, H Begthel, ... Nature 457 (7229), 608 | 1701 | 2009 |
| Linking colorectal cancer to Wnt signaling M Bienz, H Clevers Cell 103 (2), 311-320 | 1698 | 2000 |
| Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 V Korinek, N Barker, P Moerer, E van Donselaar, G Huls, PJ Peters, ... Nature genetics 19 (4), 379 | 1676 | 1998 |
| Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ... Nature 469 (7330), 415 | 1519 | 2011 |
| The cancer stem cell: premises, promises and challenges H Clevers Nature medicine 17 (3), 313 | 1498 | 2011 |
| Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells JH van Es, ME van Gijn, O Riccio, M van den Born, M Vooijs, H Begthel, ... Nature 435 (7044), 959 | 1407 | 2005 |
| Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation DA Glass II, P Bialek, JD Ahn, M Starbuck, MS Patel, H Clevers, ... Developmental cell 8 (5), 751-764 | 1307 | 2005 |
| Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF M Van de Wetering, R Cavallo, D Dooijes, M van Beest, J van Es, ... Cell 88 (6), 789-799 | 1288 | 1997 |
| Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ... Cell 143 (1), 134-144 | 1232 | 2010 |
| Stem cells, self-renewal, and differentiation in the intestinal epithelium LG Van Der Flier, H Clevers Annual review of physiology 71, 241-260 | 1227 | 2009 |
| Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ... Gastroenterology 141 (5), 1762-1772 | 1214 | 2011 |
John W. Kappler，美国丹佛市国立犹太医学中心-生物医学研究系杰出教授，Philippa Marrack，美国丹佛市国立犹太医学中心-生物医学研究系杰出教授。
获奖原因：他们通过在胸腺中克隆消除操作发现了t细胞的耐受性，增进了对类风湿关节炎、狼疮和格林-巴利综合征等自身免疫性疾病的机制的了解。
高引论文（被引频次>900次）
T cell tolerance by clonal elimination in the thymus
JW Kappler, N Roehm, P Marrack - Cell, 1987 - Elsevier
The monoclonal antibody KJ23a reacts with T cell receptors utilizing the Vβ segment Vβ17a.
T cells bearing Vβ17a+ receptors react with very high frequency with the MHC class II
protein, IE. In this paper we show that T cells expressing Vβ17a are selectively eliminated …
被引用次数：2431 相关文章 所有 9 个版本 图书馆搜索
The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice
J White, A Herman, AM Pullen, R Kubo, JW Kappler… - Cell, 1989 - Elsevier
Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man.
In this paper we show that, for mice, this is because the protein in association with major
histocompatibility complex class II molecules stimulates virtually all T cells bearing Vβ3 and …
被引用次数：1281 相关文章 所有 8 个版本 图书馆搜索
Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition
JW Kappler, B Skidmore, J White… - Journal of Experimental …, 1981 - jem.rupress.org
We developed a method for production of antigen-specific, H-2-restricted T cell hybrids. The
tumor cell partner in the fusions was itself a T cell hybrid, FS6-14.13. AG2 (or its derivatives),
which could be induced to produce the growth factor, interleukin-2 (IL-2), in response to a …
被引用次数：1204 相关文章 所有 9 个版本 图书馆搜索
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
JW Kappler, U Staerz, J White, PC Marrack - Nature, 1988 - nature.com
In mice the product of the Mls a locus is an unusual antigen capable of interaction with
certain products of the major histocompatibility locus (MHC) to form a ligand for a large
portion of the T-cell α/β receptor repertoire, including nearly all receptors that use V β8. 1 …
被引用次数：1209 相关文章 所有 7 个版本 图书馆搜索
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells
BH Koller, P Marrack, JW Kappler, O Smithies - Science, 1990 - science.sciencemag.org
Major histocompatibility class I proteins display viral and self antigens to potentially
responsive cells and are important for the maturation of T cells; beta 2-microglobulin (beta
2M) is required for their normal expression. Mouse chimeras derived from embryonic stem …
被引用次数：932 相关文章 所有 10 个版本 图书馆搜索
Superantigens: mechanism of T-cell stimulation and role in immune responses
A Herman, JW Kappler, P Marrack… - Annual review of …, 1991 - annualreviews.org
Superantigens combine with MHC class-II molecules to form the ligands that stimulate T
cells via the Vβ element of the T-cell receptor. Two groups of superantigens have been
described so far: first, endogenous murine products that include the MIs determinants, and …
高引论文（被引频次>1100次）
T cell tolerance by clonal elimination in the thymus
JW Kappler, N Roehm, P Marrack - Cell, 1987 - Elsevier
The monoclonal antibody KJ23a reacts with T cell receptors utilizing the Vβ segment Vβ17a.
T cells bearing Vβ17a+ receptors react with very high frequency with the MHC class II
protein, IE. In this paper we show that T cells expressing Vβ17a are selectively eliminated …
被引用次数：2431 相关文章 所有 9 个版本 图书馆搜索
The staphylococcal enterotoxins and their relatives
P Marrack, J Kappler - Science, 1990 - science.sciencemag.org
Staphylococcal enterotoxins and a group of related proteins made by Streptococci cause
food poisoning and shock in man and animals. These proteins share an ability to bind to
human and mouse major histocompatibility complex proteins. The complex ligand so formed …
被引用次数：2342 相关文章 所有 15 个版本 图书馆搜索
The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice
…, A Herman, AM Pullen, R Kubo, JW Kappler, P Marrack - Cell, 1989 - Elsevier
Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man.
In this paper we show that, for mice, this is because the protein in association with major
histocompatibility complex class II molecules stimulates virtually all T cells bearing Vβ3 and …
被引用次数：1281 相关文章 所有 8 个版本 图书馆搜索
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
JW Kappler, U Staerz, J White, PC Marrack - Nature, 1988 - nature.com
In mice the product of the Mls a locus is an unusual antigen capable of interaction with
certain products of the major histocompatibility locus (MHC) to form a ligand for a large
portion of the T-cell α/β receptor repertoire, including nearly all receptors that use V β8. 1 …
被引用次数：1209 相关文章 所有 7 个版本 图书馆搜索
Interaction of Staphylococcus aureus toxin" superantigens" with human T cells
…, L Herron, J Callahan, P Marrack… - Proceedings of the …, 1989 - National Acad Sciences
A modification of the polymerase chain reaction has been used to establish the fact that a
collection of Staphylococcus aureus toxins are" superantigens," each of which interacts with
the T-cell alpha beta receptor of human T cells by means of a specific set of V beta elements.
被引用次数：1109 相关文章 所有 9 个版本 图书馆搜索
Ernst Bamberg，德国法兰克福马克斯普朗克生物物理研究所名誉所长，Karl Deisseroth，美国加利福尼亚州斯坦福大学霍华德休斯医学研究所研究员，生物工程和精神病学与行为科学D. H. Chen杰出教授。
Gero Miesenbock，英国牛津大学神经回路和行为中心主任兼生理学Waynflete教授。
获奖原因：在光遗传学领域做出的贡献。该技术构成了神经科学领域的一场革命，增强了人们对帕金森病、视力恢复、成瘾和情绪障碍的认识。
高引论文（被引频次>910次）
Millisecond-timescale, genetically targeted optical control of neural activity
ES Boyden, F Zhang, E Bamberg, G Nagel… - Nature …, 2005 - nature.com
Temporally precise, noninvasive control of activity in well-defined neuronal populations is a
long-sought goal of systems neuroscience. We adapted for this purpose the naturally
occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel …
被引用次数：3551 相关文章 所有 20 个版本 图书馆搜索
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel
…, D Ollig, P Hegemann, E Bamberg - Proceedings of the …, 2003 - National Acad Sciences
Microbial-type rhodopsins are found in archaea, prokaryotes, and eukaryotes. Some of them
represent membrane ion transport proteins such as bacteriorhodopsin, a light-driven proton
pump, or channelrhodopsin-1 (ChR1), a recently identified light-gated proton channel from …
被引用次数：2061 相关文章 所有 19 个版本 图书馆搜索
Multimodal fast optical interrogation of neural circuitry
…, JF Liewald, K Kay, N Watzke, PG Wood, E Bamberg… - Nature, 2007 - nature.com
Our understanding of the cellular implementation of systems-level neural processes like
action, thought and emotion has been limited by the availability of tools to interrogate
specific classes of neural cells within intact, living brain tissue. Here we identify and develop …
被引用次数：1567 相关文章 所有 25 个版本 图书馆搜索
Channelrhodopsin-1: a light-gated proton channel in green algae
…, M Fuhrmann, S Kateriya, AM Musti, E Bamberg… - …, 2002 - science.sciencemag.org
Phototaxis and photophobic responses of green algae are mediated by rhodopsins with
microbial-type chromophores. We report a complementary DNA sequence in the green alga
Chlamydomonas reinhardtiithat encodes a microbial opsin-related protein, which we term …
被引用次数：910 相关文章 所有 15 个版本 图书馆搜索
高引论文（被引频次>1100次）
| 标题 | 引用次数 | 年份 |
|---|---|---|
| Millisecond-timescale, genetically targeted optical control of neural activity ES Boyden, F Zhang, E Bamberg, G Nagel, K Deisseroth Nature neuroscience 8 (9), 1263 | 3551 | 2005 |
| Parvalbumin neurons and gamma rhythms enhance cortical circuit performance VS Sohal, F Zhang, O Yizhar, K Deisseroth Nature 459 (7247), 698 | 1778 | 2009 |
| Driving fast-spiking cells induces gamma rhythm and controls sensory responses JA Cardin, M Carlén, K Meletis, U Knoblich, F Zhang, K Deisseroth, ... Nature 459 (7247), 663 | 1773 | 2009 |
| Multimodal fast optical interrogation of neural circuitry F Zhang, LP Wang, M Brauner, JF Liewald, K Kay, N Watzke, PG Wood, ... Nature 446 (7136), 633 | 1567 | 2007 |
| Neocortical excitation/inhibition balance in information processing and social dysfunction O Yizhar, LE Fenno, M Prigge, F Schneider, TJ Davidson, DJ O’shea, ... Nature 477 (7363), 171 | 1415 | 2011 |
| Optogenetics K Deisseroth Nature methods 8 (1), 26 | 1352 | 2011 |
| Optogenetics in neural systems O Yizhar, LE Fenno, TJ Davidson, M Mogri, K Deisseroth Neuron 71 (1), 9-34 | 1291 | 2011 |
| The development and application of optogenetics L Fenno, O Yizhar, K Deisseroth Annual review of neuroscience 34 | 1242 | 2011 |
| Optical deconstruction of parkinsonian neural circuitry V Gradinaru, M Mogri, KR Thompson, JM Henderson, K Deisseroth science 324 (5925), 354-359 | 1241 | 2009 |
| Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry AV Kravitz, BS Freeze, PRL Parker, K Kay, MT Thwin, K Deisseroth, ... Nature 466 (7306), 622 | 1218 | 2010 |
| Structural and molecular interrogation of intact biological systems K Chung, J Wallace, SY Kim, S Kalyanasundaram, AS Andalman, ... Nature 497 (7449), 332 | 1193 | 2013 |
| CREB phosphorylation and dephosphorylation: a Ca2+-and stimulus duration–dependent switch for hippocampal gene expression H Bito, K Deisseroth, RW Tsien Cell 87 (7), 1203-1214 | 1186 | 1996 |
| Neural substrates of awakening probed with optogenetic control of hypocretin neurons AR Adamantidis, F Zhang, AM Aravanis, K Deisseroth, L De Lecea Nature 450 (7168), 420 | 1117 | 2007 |
高引论文
Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state.
JR Patsch, G Miesenböck, T Hopferwieser… - … and thrombosis: a …, 1992 - Am Heart Assoc
The status of fasting triglycerides as a risk factor for coronary artery disease (CAD) has been
considered weak because in multivariate analyses, triglycerides tend to be eliminated by
high density lipoprotein (HDL) cholesterol. To further evaluate the role of triglycerides in …
被引用次数：1317 相关文章 所有 9 个版本 图书馆搜索
[HTML] Remote control of behavior through genetically targeted photostimulation of neurons
SQ Lima, G Miesenböck - Cell, 2005 - Elsevier
Optically gated ion channels were expressed in circumscribed groups of neurons in the
Drosophila CNS so that broad illumination of flies evoked action potentials only in
genetically designated target cells. Flies harboring the “phototriggers” in different sets of …
被引用次数：509 相关文章 所有 10 个版本 图书馆搜索
https://blog.sciencenet.cn/blog-212210-1199580.html
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