Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease

https://pubmed.ncbi.nlm.nih.gov/34494943/

研究主题如下

MeSH terms

• Animals

• Butyrates / metabolism

• Butyrates / pharmacology*

• Cells, Cultured

• Colitis / drug therapy

• Colitis / microbiology

• Colitis / pathology

• Cytokines / analysis

• Disease Models, Animal

• Extracellular Traps / immunology*

• Gastrointestinal Microbiome / physiology

• Histone Deacetylase Inhibitors / pharmacology

• Histone Deacetylases / metabolism

• Homeostasis / immunology

• Host Microbial Interactions / physiology

• Humans

• Hydroxamic Acids / pharmacology

• Immunity, Innate / immunology

• Inflammatory Bowel Diseases / drug therapy*

• Inflammatory Bowel Diseases / microbiology

• Inflammatory Bowel Diseases / pathology

• Intestinal Mucosa / microbiology

• Intestinal Mucosa / pathology*

• Male

• Mice

• Mice, Inbred C57BL

• Neutrophil Infiltration / drug effects*

• Neutrophils / immunology*

• Oxidative Stress / immunology

• Pertussis Toxin / pharmacology

• Receptors, G-Protein-Coupled / antagonists & inhibitors

Substances

• Butyrates

• Cytokines

• Histone Deacetylase Inhibitors

• Hydroxamic Acids

• Receptors, G-Protein-Coupled

• trichostatin A

• Pertussis Toxin

• Histone Deacetylases

Related information

• MedGen

• PubChem Compound (MeSH Keyword)

Grant support

This work was supported by grants from the National Key R&D Program of China (2018YFC1705405) and the National Natural Science Foundation of China (grant number 81630017, 91942312);

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