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国际站:Resiniferatoxin
AS:57444-62-9
品牌:MedChemExpress (MCE)
存储条件:-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
生物活性:Resiniferatoxin ((+)-Resiniferatoxin),是一种选择性 TRPV1 受体激动剂,能够从 Euphorbia resinifera 植物中提取得到。在动物模型中,Resiniferatoxin 能够在相当长的一段时间内消除 TRPV1+ 初级感觉传入和钝性心脏交感传入反射。
体外:Resiniferatoxin 导致通道开放时间延长和钙内流,从而导致对 TRPV1 阳性疼痛纤维或细胞体的细胞毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内:Resiniferatoxin (2 μg/10 μl;鞘内注射到 T2/T3 间隙;冠状动脉闭塞后 4 周诱导大鼠心力衰竭) 显著和选择性地消除背角的传入标记物表达 (TRPV1 和降钙素基因相关肽) 并减少过度激活的 CSNA。Resiniferatoxin 显著逆转动作电位持续时间 (APD) 和 APD 交替的延长,降低室性心律失常的诱发性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Clinical Trial
参考文献:
[1]. Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel). 2016;9(3):47. Published 2016 Aug 11.
[2]. Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836.
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