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- JANEWANGJK55
- those expressing a carbapenems phenotype plasmids often also carry genes encoding resistance to other commonly used antimicrobial drug classes (including aminoglycosides, cephalosporins, chloramphenicols, or fluoroquinolones).
- JANEWANGJK55
- Conjugation experiments were carried out using a broth mating protocol. (Ref) E. coli J53
- JANEWANGJK55
- In714= Salmonella enterica; Aeromonas hydrophila; IncP-1epsilon plasmids; K. p; E. coli
In27= Salmonella, E. coli, Klebsiella pneumoniae, Acinetobacter baumannii.
- JANEWANGJK55
- In Enterobacteriaceae, transposon Tn** appeared to be the main vehicle for dissemination of blaNDM-1.
IncX3-type plasmids have spread around our province, and it has been a threat in the dissemination of the blaNDM-1 gene among Enterobacteriaceae strains in China.
Interestingly, the backbone of *** is organized similarly to the backbone of IncX plasmids, which were thought to be narrow host range plasmids of Enterobacteriaceae, but the ability of transfer to Pseudomonas aeruginosa has been demonstrated. The first blaNDM-1-harboring IncX3 plasmid, pNDM-HN380, was reported in 2012 from a K. pneumonia isolate discovered in China.27
- JANEWANGJK55
- Moreover, the pKOX3-P4-IMP also showed similarity to one plasmid from K. oxytoca, pKOX105 (GenBank no. HM126016). The pKOX105 was highly related to the p9 and p12 plasmids from K. pneumoniae and K. oxytoca strains at a New York City hospital in 2005 carrying blaKPC-2 and blaKPC-3, respectively.35
- JANEWANGJK55
- Conjugation test have been performed using E. coli J53 (Azr) as a recipient, with which no transconjugant could be obtained (data not shown).
- JANEWANGJK55
- and bracketed by two copies of insertion sequence ISKpn19, which could form a composite transposon with the potential to mobilize blaKPC-2.
- JANEWANGJK55
- Analysis of the genetic environment of these three genes has demonstrated that IS** and IS*** are involved in the spread of the ** genes, while the transposable elements IS26, ** might contribute to the dissemination of the *** gene.
